sorbitan monostearate toxicity

Even when administered in doses much higher than those that would be ingested in an average diet or from a beauty regimen, sorbitan monostearate is safe for human and animal use. The Panel considered that the available reproductive and developmental toxicity studies with sorbitan monostearate have limitations but no adverse effects were reported. Test conducted under the static system for 48 hrs. Hazardous decomposition products Hazardous decomposition products Oxides of carbon. Based on the data available for the test chemical, Sorbitan monostearate, ethoxylated (CAS no 9005 -67 -8) does not exhibit gene mutation in vitro. Acute oral toxicity study of test chemical was conducted on rats at the dose concentration of 60000 mg/kg bw. He is author of other very interesting books not only on MSG or aspartame. Safety Data Sheet (Sorbitan Monostearate) DATE PREPARED: 10/26/2016 Page 2 of 6 Ingestion: Never give anything by mouth to an unconscious person.Rinse mouth with water. Based on the mortality of fish Oryzias latipes (Japanese Medaka) by the chemical incubation for 24 and 48 hrs, the LC50 was observed at 260 mg/l and 240 mg/l. It was of low acute oral toxicity to rats and repeated oral administration affected the kidney, liver and blood of rats and mice, and induced gastrointestinal disturbances in dogs and hamsters. Nutritional and pathological effects of sorbitan monolaurate, polyoxyethylene sorbitan monolaurate, polyoxyethylene monolaurate, and polyoxyethylene monostearate when fed to rats Arch Biochem Biophys. In rabbits, sorbitan monostearate was irritant when applied repeatedly to the skin. Sorbitan stearate | C24H46O6 | CID 16218600 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Sorbitan monostearate may be safely used as an emulsifier in the following food, sometimes together with polysorbate (60, 65, 80) (1): Whipped edible oil topping; Cakes and cake mixes, icings and fillings; Nonstandardized confectionery coatings and standardized cacao products; Edible vegetable fat-water emulsions in beverage coffee ; It can also be used as a rehydration aid in the … Polyoxyethylene-40-sorbitan monostearate Polysorbate 60 Sorbitan, monooctadecanoate, poly(oxy-1,2-ethanediyl) derivs. Abstract: The heterocyclic compounds, mainly carbohydrate-based surfactant, 1, 4 Sorbitan, namely (Sorbitan Mono-stearate with 20 moles of Ethylene oxide SMS-20-EO, Sorbitan Mono-oleate SMO, and Sorbitan Mono-oleate ethoxylated with 20 moles of Ethylene oxide SMO-20-EO ) have been synthesized and characterized through different spectroscopic methods (FTIR, 1H NMR). Short term toxicity of test chemical were studied on the mortality of fish Oryzias latipes (Japanese Medaka). The test chemical was dissolved in distilled water or DMSO as the solvent and used at dose level of 0, 10, 100, 200, 1000 or 2000 µg/plate. I deleted the section on the toxicology of sorbitan monostearate, known worldwide as "Span 60". Product Name Sorbitan monostearate Cat No. Toxicity was reported in subchronic and chronic studies at concentrations above that normally used in cosmetics. Welcome to PubChem! Of course, I threw that dough away! Information on toxicological effects Toxicological effects Not regarded as a health hazard under current legislation. : L11435 CAS-No 1338-41-6 Synonyms No information available Recommended Use Laboratory chemicals. It acts as a humectant to bind moisture, thicken the product, and stabilize the mixture of water and oils. General information; Classification & Labelling & PBT assessment; Manufacture, use & exposure Nutritional and pathological effects of sorbitan monolaurate, polyoxyethylene sorbitan monolaurate, polyoxyethylene monolaurate, and polyoxyethylene monostearate when fed to rats. General information; Classification & Labelling & PBT assessment; Manufacture, use & exposure In subchronic and chronic oral toxicity studies, PEGs did not cause adverse reproductive effects. Skin and Eye Irritation and References. Gene mutation toxicity study was performed to determine the mutagenic nature of the test chemical. Hence the test chemical is not likely to classify as a gene mutant in vitro. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. This website and underlying databases are maintained and updated by Pesticide Action Network North America (PAN). Sorbitan monostearate is a common ingredient used in many industries and products. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. ingram aj et al; short-term toxicity study of sorbitan mono-oleate (span 80) in rats; food cosmet toxicol 16(6) 535 (1978) Hazardous Substances Data Bank (HSDB) 13 Literature The Sorbitan esters, including Sorbitan Stearate, Sorbitan Laurate, Sorbitan Sesquioleate, Sorbitan Oleate, Sorbitan Tristearate, Sorbitan Palmitate, and Sorbitan Trioleate, are used in cosmetic products as emulsifiers and stabilizers at concentrations normally under 5 percent. Sorbitans are a group of compounds derived from sorbitol, a sugar alcohol.8 Joseph Boussin, a French chemist, first isolated sorbitol from berries in 1872.11 Notable sorbitan derivatives include sorbitan sesquioleate (SSO), sorbitan monooleate (SMO), sorbitan monostearate (SMS) and polysorbate.8 SSO is fatty acid ester formed from mono- and diesters of oleic acid and hexitol … Tween 60. Extensive human and animal testing have show little to no adverse health effects. The test chemical was administered via oral unspecified route. Long-term toxicity study of sorbitan monostearate (Span 60) in mice Sorbitan monostearate is a waxy powder that is used as an emulsifier that keep water and oils mixed. It is produced from sorbitol and stearic acid, which is a normal fatty acid from vegetable or animal origin.The substance is used in the production of some food and healthcare products. EC number: 500-020-4 | CAS number: 9005-67-8 1 - 6.5 moles ethoxylated . Referenced studies on the toxicology of sorbitan monolaurate, ethoxylated and sorbitan monostearate the... In cosmetics by FDA in quantities not exceeding the amount reasonably required to the! With sorbitan monostearate is a non-ionic surfactant with emulsifying, dispersing, and polyoxyethylene monostearate when fed to rats FDA! 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